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Substantia Nigra — The Dopamine Powerhouse_ Part 3 The substantia nigra has two functional parts. The pars compacta provides dopaminergic modulation to the basal ganglia, while the pars reticulata acts as a major output nucleus. Its degeneration is central to Parkinson’s disease, making this structure clinically vital. #SubstantiaNigra #Dopamine #ParkinsonsDisease #BasalGanglia #Neuroanatomy | Adeel Ur Rehman
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Basal Ganglia Part II The basal ganglia are deep subcortical grey matter nuclei embedded within cerebral white matter. They include the striatum (caudate nucleus putamen), globus pallidus (external GPe and internal GPi segments), subthalamic nucleus (STN), and substantia nigra (pars compacta and pars reticulata). The striatum is the main input nucleus; GPi and substantia nigra pars reticulata act as output nuclei. The STN, composed of excitatory glutamatergic neurons, lies at the diencephalon–mi
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