Recent studies show that senescent cells accumulate several species of cytosolic DNAs, including mitochondrial DNA (mtDNA), cytoplasmic chromatin fragments (CCFs), and retrotransposable element cDNAs, ...

Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitoch ...

Watching mainstream science in America under attack by the US federal and many state governments, most scientists and health ...

The epithelial–mesenchymal transition (EMT) is a source of cancer cell plasticity and tumour heterogeneity, and is ...

From the Human Genome Project to large-scale initiatives like the UK Biobank and The Cancer Genome Atlas (TCGA), the recent ...

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Double‐stranded RNA induces a post‐transcriptional gene silencing process, termed RNAi, in diverse organisms. It is shown here that transcriptional gene silencing accompanied by de novo methylation of ...

For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

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