Watching mainstream science in America under attack by the US federal and many state governments, most scientists and health ...

The epithelial–mesenchymal transition (EMT) is a source of cancer cell plasticity and tumour heterogeneity, and is ...

From the Human Genome Project to large-scale initiatives like the UK Biobank and The Cancer Genome Atlas (TCGA), the recent ...

Mitogen‐activated protein kinase (MAPK) cascades are important signaling modules regulating diverse biological processes. During the past 20 years, much progress has been made on the functions of MAPK ...

For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

The dedifferentiation of somatic cells into a pluripotent state by cellular reprogramming coincides with a reversal of age-associated molecular hallmarks. Although transcription factor induced ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

More broadly, these findings contribute to an emerging view in which neuronal health depends on the orchestration of long-range cellular trafficking and local stress responses. By uncovering a system ...

Activation of cell death pathways typically leads to the irreversible destruction of the cell. However, in this issue of The ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Studying the human immune system in vivo is ...