This fundamental work demonstrates that compartmentalized cellular metabolism is a dominant input into cell size control in a variety of mammalian cell types and in Drosophila. The authors show that ...
A naturally occurring metabolic compound, pyruvate, has been identified as a potent suppressor of inflammation in ulcerative colitis (UC), offering a promising new strategy for treating this chronic ...
Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...
Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...
Scientists have cracked the structure of the mitochondrial pyruvate carrier, a fuel gate inside our cells, after 50 years of speculation. The discovery could revolutionize treatment strategies for ...
A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, and David ...
The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...
aInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan bDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National ...
Department of Critical Care Medicine, The Affiliated Huaian No 1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, China Sepsis-associated acute kidney injury presents as a critical ...
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, P. R. China State Key Laboratory of ...
NICE is unable to make a recommendation on mitapivat (Pyrukynd) for treating pyruvate kinase deficiency in adults because Agios did not provide an evidence submission. We will review this decision if ...
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