Objective Randomised controlled trials (RCT) offer an opportunity to learn about frequency and character of adverse drug reactions. To improve the quality of reporting adverse effects, the Consort ...

SMA is a motor neuron disease characterised by generalised muscle atrophy and weakness. It is caused by the dysfunction and eventual death of motor neurons, due to deletions of SMN1 in 95% of patients ...

Background and Objectives Prolonged neonatal jaundice is defined as jaundice persisting in a term neonate at 14 days and a preterm neonate at 21 days of age. Prolonged neonatal jaundice is most ...

Objective To investigate a possible association between fever admissions and 4 component Meningococcal B (4CMenB). Design 4CMenB is given at 8 and 16 weeks in the first year of life. Self-controlled ...

Purpose Children with Trisomy 21 are at increased risk of death compared to age-matched controls. We recently undertook a retrospective review of mortality in Trisomy 21 in our tertiary non-cardiac ...

Background Mental health problems are prevalent in children and young people (CYP). Children with neurodevelopmental disorders such as ASD have co-morbid mental health difficulties which add to the ...

Aims To explore the experiences and perceptions of senior medical and nursing staff regarding the advance care plan (ACP) in children and young persons (CYP) with life-limiting conditions and ...

Aims Maternal breastmilk (MBM) is the one of the most important interventions a preterm infant can receive. It reduces morbidity, improves neurodevelopmental outcome and reduces the incidence of ...

The investigation of global developmental delay in preschool children varies between centres and between paediatricians. [1] [1] Following a literature search and review of the evidence base, ...

Methods We used novel linkage between health and education records from the Education and Child Health Insights from Linked Data (ECHILD) database to develop a whole-country cohort of children ...

Background The use of biologic agents allows the application of precision medicine in the treatment of paediatric severe asthma. Aim To describe the real-life effectiveness of biologic agents in ...

Objectives Critical appraisal and evidence based medicine (EBM) are ‘academic’ skills that guide daily practice and drive improvements in patient care, and are thus essential components of the ...