There may soon be a new way to prevent deaths from fentanyl. A preventative vaccine for fentanyl exposure that could prevent the symptoms of overdose is set to begin human trials and could change the landscape of drug overdoses in the U.S.

In 2024, 761 people died in Colorado from a fentanyl overdose. That represents a decrease from other recent years but is still far more fentanyl-related deaths than even five years prior.

A black SUV, seen in a video, might have had occupants who witnessed events leading to the fentanyl-related death.

The DEA's Chicago Field Division reports a significant increase in fentanyl seizures and arrests in 2025. | A live look at what happened today, what’s happening now, and what’s coming tonight—no script,