Background: Subclinical hypothyroidism has been linked to adverse renal outcomes, but it is unknown whether treatment of subclinical hypothyroidism reduces the risk of these adverse outcomes. We ...

Key points Canada’s health systems are stressed with increasing demands for health care and services. The causes of this stress are multifactorial and include an aging population and a health ...

Key points The provision of health care is hard and, understandably, clinicians struggle. Beyond meaningful health care interactions, clinicians must also integrate large volumes of demographic, ...

Care should include explicit statements affirming patient choice. Clinicians with faith-based objections should provide timely, tolerant referral; judgmental or obstructive care may result in ...

Figure 1: (A) Peripheral blood smear showing erythrocytes with basophilic stippling (arrows) in a 47-year-old male plumber with lead poisoning. (B) Burton line (arrows) in some of the patient’s gum ...

Figure 1: (A) Numerous black–brown granules attached to the left eyelashes and eyelids of a 77-year-old woman with phthiriasis palpebrarum. (B) Dermoscopy showed multiple lice and ovoid nits on the ...

KEY POINTS Clinicians may be concerned about the potential of electronic patient portals to disrupt the therapeutic relationship, deliver medicolegal burdens or harm patients, but these fears are ...

Obstructive sleep apnea in children peaks around age 4–6 years Obstructive sleep apnea (OSA) is characterized by partial or complete airway obstruction during sleep. Prevalence is about 1.2%. 1 ...

KEY POINTS Multifactorial early-pregnancy screening for preeclampsia can identify most patients at risk, particularly of early-onset, severe disease. Prophylaxis with acetylsalicylic acid (ASA) can ...

HIV-1 can be successfully treated with long-acting injectable antiretroviral therapy A dual regimen combining the integrase strand transfer inhibitor cabotegravir with the nonnucleoside reverse ...

KEY POINTS In most medical subspecialties, genetic and genomic testing have become a routine part of clinical care. However, access to genetic testing at the patient, provider, and provincial levels ...

Normal prolactin levels are less than 25 μg/L in females and less than 20 μg/L in males.[1][1] Measurement is indicated for erectile or ejaculatory dysfunction, amenorrhea, oligomenorrhea, infertility ...