ABSTRACT: Bone is a frequent site of cancer metastasis. Bone metastases can result in bone destruction or new bone formation. Bone destruction is mediated by factors produced or induced by tumor cells ...
Drinking milk helps your bones grow big and strong, but what if direct exposure to light could help, too? Now, researchers from Japan report that lighting up bone tissue could help treat bone disease.
Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation. During late-stage differentiation, osteoclasts ...
Osteoporosis (OP) is a disorder of bone remodeling caused by an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Therefore, inhibiting excessive osteoclast activity ...
Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, causing pain, fractures, and decreased quality of life. These conditions often ...
Three water-soluble egg yolk fractions (FA, FB, and FC) and subfractions of FC (FC1 (< 3 kDa) and FC2 (> 3 kDa)) showed promising osteoclastogenesis inhibitory effects by suppressing osteoclast ...
Nanozyme-modified polyethylene liners reduced wear debris and made remaining particles less inflammatory, lowering oxidative stress and bone loss in implant models.
Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...
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