Parkinson's disease (PD) is the second most common neurodegenerative disorder, primarily characterized by motor dysfunction. Its pathological hallmark is the abnormal aggregation of α-synuclein (α-syn ...

In a recent study published in Progress in Neurobiology, researchers discover that the substantia nigra of individuals with Parkinson’s disease had a higher concentration of pheomelanin, as well as ...

Corresponding Author: Zhenyu Yue, PhD, Director of The Center for Parkinson's Disease Neurobiology, Icahn School of Medicine at Mount Sinai; Bin Zhang, PhD, Director of the Mount Sinai Center for ...

There are three dopaminergic pathways, namely the striatonigral pathway (substantia nigra to caudate and putamen), the mesolimbic pathway (ventral tegmental area of midbrain to limbic areas of basal ...

Parkinson’s disease (PD) is a neurodegenerative disorder marked by the selective loss of midbrain dopamine (mDA) neurons in the substantia nigra. Human pluripotent stem cells (hPSCs) offer a promising ...