MRD status before allo-HSCT is a strong prognostic factor for OS, DFS, and CIR in AML and MDS patients. MRD-negative patients showed significantly better OS and DFS compared to MRD-positive patients, ...
In the 1980s, the Rijswijk TNO group including Ton Hagenbeek and Dirk van Bekkum developed the term minimal residual disease (MRD) on the basis of nifty experiments in a rat model of AML. In 1983–1990 ...
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