Intestinal epithelial cells (IECs) are more than a passive barrier; they serve as non-professional antigen-presenting cells by expressing major histocompatibility complex class II (MHC class II) ...
Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...
MHC-I presents peptides derived from endogenous antigens. Antigen is proteolyzed by the immune proteasome and specific peptides loaded to MHC-I. The resulting MHC-I–peptide complex is transported to ...
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