Cells synthesize proteins in the endoplasmic reticulum (ER), and these proteins are transported to the Golgi apparatus for distribution to their ultimate destinations inside and outside the cell. The ...

Autophagy is an intracellular degradation mechanism in eukaryotes. The autophagosome, which encloses damaged or excess ...

One of the major challenges in the quest to beat cancer is developing treatments that can selectively destroy cancer cells while leaving healthy cells unharmed. With this in mind, researchers at the ...

Autophagy is an intracellular degradation mechanism in eukaryotes. The autophagosome, which encloses damaged or excess ...

A study in budding yeast suggests that changes in membrane lipids trigger a braking system that slows internal protein ...

Excess cellular cholesterol induces apoptosis in macrophages, an event likely to promote progression of atherosclerosis. The cellular mechanism of cholesterol-induced apoptosis is unknown but had ...

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a new ...

Aberrant proteins are extremely harmful to cells. Such proteins can originate from mutations, unbalanced subunit synthesis, damaging conditions (for example, oxidation) and also as a side product of ...

Advanced imaging revealed that sunitinib concentrates in lysosomes and progressively disrupts mitochondrial and endoplasmic ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of ...