The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in which ...

CHANGE-seq-BE was developed to enable scientists to better understand base editors, an important class of CRISPR precise genome editors.

Scientists and physicians can better assess precision genome editing technology using a new method made public today by St.

Structural variations (SVs), including insertions, deletions, inversions, and substitutions, can profoundly influence gene ...

The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick geometry. However, they can also adopt alternate Hoogsteen conformations in various complexes of DNA with proteins ...

Study Shows How Melting Point Analysis Infers the Presence of and Identifies SNPs The melting temperature (T m) of a PCR product is dependent on both the length and sequence of the DNA. Melting curve ...

The completion of a South American lung fish genome sequencing represents one of the most remarkable moments within current ...

This image illustrates the chemical structures of the five main nucleobases found in DNA and RNA. The pyrimidines, thymine (DNA), uracil (RNA), and cytosine are shown on top while the purines, adenine ...

Scientists have for the first time been able to build a organism containing a new, synthetic pair of DNA units, marking a breakthrough in the field of synthetic biology that has major implications for ...