The regulation of chromatin accessibility across the genome (that is, global accessibility) remains unclear because prior work has focused primarily on nucleosome-depleted regions (NDRs) (that is, ...

Chromatin organization plays a crucial role in both embryonic development 1,2 and the progression of various diseases 3,4. During development, the chromatin structure influences which genes are turned ...

Certain epigenetic modifications can directly control how genetic material is packed in the nucleus, RIKEN researchers have shown. This has important implications for our understanding of how genes ...

This study is led by Dr. Yue Zhou (State Key Laboratory of Gene Function and Modulation Research, School of Advanced Agricultural Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, ...

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome. Those interactions depend on the ability of chromatin—a mix of DNA and ...

Figure 1: RIKEN researchers have succeeded in reconstituting long stretches of chromatin arrays. In this atomic force microscopy image, the reconstituted chromatin ...