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Cambrian Bio records a positive human trial with its AMPK activator drug, ATX-304

Scientists may have finally found a way to safely restore AMPK function in humans, a milestone many researchers in the aging ...
EurekAlert!

SOX9 overexpression ameliorates metabolic dysfunction-associated steatohepatitis through activation of the AMPK pathway

Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...
Nature

AMPK Signaling in Cancer Metabolism

Adenosine monophosphate–activated protein kinase (AMPK) is a central metabolic sensor that maintains cellular energy homeostasis by coordinating catabolic and anabolic pathways. In cancer cells, ...

SCYNEXIS Initiates Phase 1 Study of SCY-770, a Novel AMPK Activator for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

(NASDAQ: SCYX), a clinical-stage biotechnology company advancing novel therapies for severe rare diseases, today announced initiation of a Phase 1 study of SCY-770, a first-in-class, potent and direct ...
EurekAlert!

Researchers identify potential new strategy to slow the development of liver fibrosis

Activating the PPARβ/δ-AMPK metabolic pathway could be an effective strategy to tackle the most common chronic liver disease in the world’s population. A study led by Manuel Vázquez Carrera, group ...