SportsLine's computer model revealed its three best MLB money-line picks for Wednesday night, which would return just over +600 in a parlay

The Braves’ Spencer Strider was scheduled to pitch Tuesday but re-injured his throwing arm playing catch. The Cards are in Hotlanta. St. Louis’ Andre Pallante has given up six runs in 10 ¹/₃ road innings, and the Red Birds are 1-10 on the road. Yes, road kill. We will take the Bravos — no matter who subs for Strider — for $50.

The following MLB betting trends are a collection of analytical data, betting systems and strength ratings featured on VSiN and qualified for the MLB games of Monday, April 21, 2025. This report is meant to emulate the process that Steve Makinen and other members of the VSiN Analytics team undergo when handicapping each day’s MLB board.