Iran's stance directly clashes with U.S. President Donald Trump 's position that Iran must halt all enrichment amid negotiations marked by uncertainty, despite having reached their most significant step since they began in April with a U.S. offer being delivered to Tehran last week.

Iran’s supreme leader, Ayatollah Ali Khamenei, said on Wednesday that abandoning uranium enrichment was “100 percent” against Tehran’s interests, effectively rejecting a key U.S. demand in weeks of tense negotiations over Iran’s nuclear program.

An Iranian diplomat dismissed the proposal as a "non-starter" that fails to address Tehran's interests or soften Washington's stance on uranium enrichment.